SBE 13 hydrochloride( SBE13 | SBE 13 | SBE13 | SBE-13 HCl )

Catalog No. M17781 CAS No. 1052532-15-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

SBE 13 hydrochloride
Note

Research use only, not for human use.
Brief Description

SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.
Description

SBE-13 is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μ M for PLK1, PLK3 and PLK2 respectively).
In Vitro

SBE13 significantly reduce cell proliferation and induce apoptosis in HeLa cells, with an EC50 of 18?μM. SBE13 (1-100 μM) shows no effect on Caspase 3/7 activity in NIH-3T3 cells. SBE13 (66 and 100 μM) does not change morphology after treatment of primary cells. SBE13 (10 and 100 μM) reduces pRb staining in primary cells, and this indicates a G0/G1 arrest. SBE13 (66 and 100 μM) increases levels of cyclin B1, phospho histone H3, Wee1, Emi1 and securin, and results in cleavage of Cdc27 in HeLa cells. SBE13 (10 and 100 μM) also induces apoptosis of HeLa cells.
In Vivo

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Synonyms

SBE13 | SBE 13 | SBE13 | SBE-13 HCl
Pathway

Others
Target

Other Targets
Recptor

PLK1| PLK2| PLK3
Research Area

Cancer
Indication

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CAS Number

1052532-15-6
Formula Weight

479.4
Molecular Formula

C24H28Cl2N2O4
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 42 mg/mL; 87.61 mM
SMILES

Clc1ncc(COc2c(OC)cc(CNCCc3cc(OC)c(OC)cc3)cc2)cc1.Cl
Chemical Name

N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine hydrochloride

1. Keppner S, et al. ChemMedChem. 2009 Nov;4(11):1806-9.2. Lange L, et al. Oncotarget. 2014 Apr 30;5(8):2263-75.

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